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Pragmatic trial design to compare real-world effectiveness of different treatments for inflammatory bowel diseases: the PRACTICE-IBD European consensus

found that diltiazem can be metabolized by Bacteroides thetaiotaomicron ( Bacteroides dorei in the gut microbiota of spontaneously hypertensive rat (SHR) was negatively correlated with the maximum concentration and elimination half-life of nifedipine, suggesting that Bacteroides dorei may possess enzyme activity capable of directly metabolizing nifedipine

In the FA-AKI model, FA-induced ferroptosis exacerbated renal injury by triggering inflammation to induce other types of cell death, consistent with the increase in the expression of TWEAK and Fn14 in renal tubular epithelial cells in the AKI context [164,165,166]

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